Although the Victoria Line runs out East-ish, lots of East and North-East London is exceptionally bad for connnections to Canary Wharf.
Several perfectly nice people I work with live either side of the eastward reaches of the river - Wapping north, and Rotherhithe to the south, and seem to like it. Both of these are recently developed with purpose-built flats (apartments) which are likely to be more or less trouble-free and may even have decent cable/fibre connections. However you really should walk around any area during the day on a working day to see what the non-commuting denizens are like. Lots of East, and West, South, and North, London is pretty hairy and the scary bits are often cheek-by-jowl with nice bits. eg, Stoke Newington - organic enclave in Hackney - is nice if a bit up-its-own-arse and hand-knitted, but estate agents will extend its borders into Dalston which gets pretty interesting at night. Imagine Asheville, NC with the most boarded-up part of Durham, NC across the road, complete with crack dens. That said, Hackney generally has some lovely bits and some extremely handsome housing/treelined streets. Hackney is famously, although North of the river, not on the tube.
No idea what your budget is but if you want to stay relatively handy in the North, you might look at Holloway, particularly Lower Holloway, around Waitrose/the women's prison (really). Very nice streets, still fairly affordable, one stop outside Zone 1 on the Piccadilly Line which, because it runs to Heathrow, is generally reliable and runs later and earlier than most others. Also it has air steward(esse)s doing their faces on it at any time of day, which I think of as an iconic London sight. Upper Holloway and Archway are slightly further out but also OK - all of these areas have some nice pubs, nice streets and some scary social housing, and horrible main roads which are little less than freeways cutting throough their centres.
Things to do: see live music. Good venues include the Luminaire in Kilburn and Spitz at Spitalfield Market although this will depend on what you like listening to/watching. There are hundreds of tiny places with all sorts of things on, from pub bands to ferocious but tiny club nights. Start with Time Out or a genre-specfic website and work outwards from there.
Buy women's shoes; every time I have been on holiday in the US even what I thought were my boring work/driving shoes have caused a (positive) stir.
Depending on your job, get a fancy haircut - not necessarily a Hoxton jokewig, but our posh hairdressers are still 60% cheaper, and 70% less conservative, than their equivalents in LA, NY and Chicago.
Learn to drink. Don't, please, learn to lark about on the pavements shouting and singing and conducting courtships that everyone else wishes you would keep private. But there is a lot of fun to be had sitting in a nice pub with nice people for a few hours. Fewer laptops than Starbucks, for a start.