SciTech

Turning The Corner In The War On Cancer?

port1080.

Posted to SciTech on Mon Jan 22, 2007 at 02:34:01 PM EST (promoted by 1fastdog). RSS.

According to the American Cancer Society's annual review of death certificates, Cancer deaths in the United States have dropped for the second straight year. This year the ACS measured the change from 2003-2004 and found a drop of over 3000 deaths, an eight times larger drop than the 369 fewer deaths found in the 2002-2003 data.

The ACS and field experts attribute the decline to a variety of factors, but especially to a combination of improved treatments, fewer smokers, and increasing use of aggressive screenings for early detection. Colorectal cancer saw the largest drop off in deaths, due mainly to new screening methods. Lung cancer also dropped in men, but seems to have plateaued in women for the time being. As John R. Seffrin, CEO of the ACS notes, "This second consecutive drop in the number of actual cancer deaths, much steeper than the first, shows last year's historic drop was no fluke."

Health statisticians have long claimed that cancer deaths have been declining as a percentage (at a rate of about 1% a year), but the absolute numbers have until now continued to climb due to the increasing average age of the US population. This drop seems to signal that doctors and scientists and getting a handle on treating cancer. Will a true cure come soon, or is this drop likely to plateau out as the law of diminishing returns kicks into effect?

logan has an interesting answer for a portion of the question posed at the end of port1080's w/up: Will a true cure come soon? Here's what logan brings to our attention: (ed)

"Funny, we seem to have discovered a cure for most cancers. It's safe, non-toxic, and could save literally millions of lives. Here's the problem: it's cheap. Really cheap. And there's no patent, so anyone can make it. That means that there's no profit in it for the drug companies, or at least not enough profit, or to go the whole nine on cynicism, not as much profit as there is in selling treatments that don't work as well." - logan

Tags: written by port1080, edited by 1fastdog, cancer, ACS, dichloroacetate, detection, screening (all tags)

This story: 10 comments (3 from subqueue)
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1

Pass the Salt

wetkarma.

Mon Jan 22, 2007 at 04:04:52 PM EST

none

So very skeptical.

$2 a dose for a product already approved for human use and you say you need $400-600m for human trials? Skeptical.

Memory is a strange bell, jubilee and knell.

3

^ 1

Re: Pass the Salt

rEvolution inAction.

Tue Jan 23, 2007 at 01:42:40 AM EST

3.00 (astute)

I read about that last week. DCA? something acetate... whatever.. Apparently it works like most other chemotherapies but it doesn't harm healthy cells.. So far they've only seen that reaction in lab rats that had human cancers so the clinical trials (a requirement before it can be used by the general public) will have to be done.. and those cost an arm and a leg. Personally if I had cancer I'd be drowning myself in the stuff.. at 2$ a pop it shouldn't be hard to find an iliicit source for it.

Tipping Sacred Cows

2

Wither Cancer?

logan.

Mon Jan 22, 2007 at 11:50:06 PM EST

none

It's funny, Cancer is the ultimate disease. It's the trump card, the Big C, the one that ends all arguments. The cure for cancer has been the holy grail of medical science since treatment for warts and the Evil Eye stopped being Doctors' bread and butter. Imagine for a moment a world where cancer is as treatable as the flu.

Millions of people every year, half a million in the US alone, would survive. About 40% of them would smoke. Hundreds of chemicals now illegal because of their carcinogenic properties would still be on the market.

Consider the nuclear industry. It's not giant explosions that we fear, it's radiation and toxic waste. Why? They cause cancer. Imagine a world where a simple inoculation or a handful of pills wold make it entirely safe to live next door to a nuclear waste site. Free energy forever would be the dream, one that might come true.

On the other hand, think of all the things that are unpleasant that are only illegal because they're cancerous. After years of living in states where smoking is banned in restaurants, I'd forgotten how distasteful the smell of tobacco is when you're trying to eat. Without the threat of cancer, virtually every bar, restaurant, and bowling alley would be filled with a blue haze.

Imagine a world where Cleveland firemen kept a watchful eye on the Cuyahoga river in case it caught fire again. Imagine the concern not being about the carcinogens in the water supply but simple aesthetics, then imagine how hard it would be to get the river cleaned up when the only complaint was the smell.

Imagine a world where air pollution was considered a regrettable, but necessary tradeoff for modern life. Sure, the air's brown and you can't see more than 100 yards, but I've got to get to work, dammit! OK, that one's not much of a stretch considering the whole SUV thing, but imagine if the catalytic converters were out and the lead was back in. Do any of us really want the entire world to look like Beijing?

Now, I'm not advocating FOR cancer, per se. But what I am saying is that fear of cancer has forced us to clean up after ourselves a little more. In a world without cancer, will we lead perfectly healthy lives in a giant toxic waste dump?

-=Logan
Spockmate!

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Re: Wither Cancer?

harzerkatze.

Tue Jan 23, 2007 at 08:35:36 AM EST

none

Consider the nuclear industry. It's not giant explosions that we fear, it's radiation and toxic waste. Why? They cause cancer. Imagine a world where a simple inoculation or a handful of pills wold make it entirely safe to live next door to a nuclear waste site. Free energy forever would be the dream, one that might come true.

While an interesting thought experiment, your approach is not entirely true. Radioactivity has different negative effects, of which cancer is only the most feared. Radiation can lead to radiantion poisoning in high doses, but even small doses can e.g. irreparably damage the DNA, thus making you sterile.
Thus, even after a cure for cancer, nuclear waste would still be hazardous.

5

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Re: Wither Cancer?

nmiguy.

Tue Jan 23, 2007 at 11:59:10 AM EST

none

Wow Logan, that is one of the most twisted things I have read in a while.  

Cancer is not the reason we clean up toxic waste or fear nuclear weapons.  

Look people drive cars and honestly want to prevent the nasty emissions for many reasons.  Cancer is seldom cited as one of the reasons.  People clean up toxic waste not just because of cancer, but because it is TOXIC and can kill or destroy the habitat.  People fear nuclear weapons because they are the ultimate Earth destroyer.  It isn't the cancer per se, but everything.  And while people do fear and hate cancer, so many smoke cigarettes and live unhealthy lifestyles, risking their lives.  

I am not going to believe that cancer brings so much good to the world.  Right now, my only brother is battling cancer.  The sooner cancer is defeated the better.  

Wither cancer?  Whither cancer.

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Re: Wither Cancer?

logan.

Tue Jan 23, 2007 at 01:32:55 PM EST

none

Wow Logan, that is one of the most twisted things I have read in a while.

Thank you. You should check out my Christmas letters. I usually manage to work in the term "Hot Carl".  

I am not going to believe that cancer brings so much good to the world.

Neither will I. Cancer is so bad that there are no metaphors to describe its effect. Cancer is the metaphor we use to describe the worst things in our society.

My post is almost purely a thought experiment, as harzerkatze suggested above. Corrections of anything I got wrong is not only appreciated, but welcomed. My desire is only to provoke a different approach in thinking about cancer's effect on society and to envision a world without cancer. While eliminating cancer would be unarguably good, it won't make life a big beach party where we're all holding hands and dancing around the rainbow while elves prance around on lilac-scented unicorns dispensing chocolate and handjobs. We will still have to get up and go to work in the morning.

That said, my thoughts and hopes go out to your brother. I wish him a complete and speedy recovery.

-=Logan
Spockmate!

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Re: Wither Cancer?

nmiguy.

Wed Jan 24, 2007 at 09:28:43 AM EST

none

Thanks Logan.  I think he is going to beat cancer.  

I was still hoping for a cure to cancer and then the big beach party, hand holding, rainbows, elves, lilac scented unicorns, chocolate and handjobs.  But I'll settle for my brother being in the clear.  

9

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Bah.

gerrymander.

Wed Jan 24, 2007 at 11:58:50 AM EST

none

In a world where cancer is a treatable disease, some other health concern would take its place. People who smoke would be less likely to die of lung cancer, and more likely to die of heart debilitation and respiratory disorders. That trend will continue until medicine solves all seven morbidity problems*. After that, it'll be "all airbags, all the time," as death by stupidity becomes the number one concern.

* The seven, in brief: cell death without replacement; cell component death without replacement; DNA transcription error; abnormal cell reproduction; energy transfer among cells; energy transfer within cells; toxin removal. All cancers fall under "abnormal cell reproduction."

7

DCA

thefadd.

Tue Jan 23, 2007 at 06:08:15 PM EST

none

From my layman's perspective, DCA looks rather believable to me given that a sizable number of people have beaten cancer by removing excess sugars and wheat from their diet and otherwise adhering to macrobiotic principles.

It is easy to buy small plaster models of what you think life is like.

10

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Re: DCA

humorlesscretin.

Fri Jan 26, 2007 at 04:05:23 AM EST

none

I have no clue about the validity of the claims for the drug, but it's clearly worth a good look.  Silly question: why aren't doctors prescribing DCA off-label for otherwise untreatable cases?  DCA's already approved for use in humans to treat lactic acidosis, so in theory any doctor who wanted to could prescribe it as a "hail Mary" treatment if nothing else.  If your patient's going to die anyway and is amenable to the attempt, why not?  If it fails, you've at least got data; if it succeeds, you've saved a life for pocket change. (I ask mainly because DCA sounds a lot more plausible than some of the wacky crap an aunt of mine who died in 2005 tried.)

Humorless. Cretinous. What'd you expect?

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